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[Multiple sclerosis and lupus].

P Devos, A Destée, L Prin

    Revue Neurologique
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This case study explores a rare instance of multiple sclerosis initially presenting as neurological deficits, later co-occurring with lupus erythematosus. The findings highlight the complex interplay between these autoimmune diseases.

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    Area of Science:

    • Neurology
    • Immunology
    • Rheumatology

    Background:

    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • Lupus erythematosus (LE) is a systemic autoimmune disease with diverse clinical manifestations.
    • The co-occurrence of MS and LE is exceptionally rare in clinical practice.

    Observation:

    • A patient presented with paraplegia at age 20, later diagnosed with multiple sclerosis based on recurrent neurological episodes and cerebrospinal fluid abnormalities.
    • At age 62, the patient developed articular lesions, Raynaud's phenomenon, and buccal ulcers, indicative of lupus erythematosus.
    • Diagnostic markers for lupus, including LE cells and specific autoantibodies (anti-native DNA, anti-Sm), were identified.

    Findings:

    • The study documents a unique case where neurological symptoms suggestive of MS preceded the overt clinical and serological diagnosis of LE by over four decades.

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  • Cerebrospinal fluid analysis revealed pleocytosis, hypergammaglobulin levels, and an elevated Delpech's ratio, consistent with MS.
  • Immunological findings confirmed the presence of lupus, including LE cells and antibodies against native DNA and Sm antigens.

    • Implications:

    • This case underscores the diagnostic challenges posed by autoimmune diseases with prolonged, disparate clinical presentations.
    • It raises questions about potential shared underlying immunological mechanisms or triggers in co-occurring autoimmune conditions.
    • Further research into the rare association of multiple sclerosis and lupus erythematosus may offer insights into autoimmune disease pathogenesis and management.