[Configuration and properties of a binding site for thyroid hormones on a specific receptor]

An analysis has been carried out of data available in literature on structure-function relationships for thyroid hormones, namely thyroxine, triiodothyronine and their analogues. The configuration and dimensions of the hormone-binding site of the receptor in a hormone-receptor complex are described. The receptor is shown to have a strained conformation in the complex. The analysis is indicative of the existence of two types of hormone-receptor complexes, a particular type being determined by the dimensions of analogues.