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An interaction of testosterone with cell membranes
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|September 1, 1984
Abstract:
The existence of an early effect of testosterone, prior to the effects dependent upon interaction between the hormone-citosolic receptor complex and the cellular nucleus, has been explored in the present paper, in 3-day old chickens. Liver glycogen phosphorylase activity is increased before protein synthesis activation, and furthermore this effect is not blocked by antibiotics (actinomicin D and cycloheximide) inhibitor of protein synthesis. When liver phosphorylase is activated, cAMP levels are not enhanced, as would be expected, but deeply depleted. The hypothesis of a phosphorylase-kinase activation due to an increase in the intracellular Ca++ concentration is considered.