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Mitogens increase phosphorylation of phosphoinositides in thymocytes

M V Taylor, J C Metcalfe, T R Hesketh

    Nature
    |November 5, 1984
    PubMed
    Summary

    Ligand-receptor interactions trigger phosphatidylinositol 4,5-bisphosphate breakdown and resynthesis. Mitogens like TPA, A23187, and Con A increase phosphatidylinositol phosphorylation in mouse thymocytes, suggesting a common signaling pathway.

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