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Related Experiment Videos

Paramagnetic pharmaceuticals for magnetic resonance imaging.

G E Wesbey, B L Engelstad, R C Brasch

    Physiological Chemistry and Physics and Medical NMR
    |January 1, 1984
    PubMed
    Summary

    Paramagnetic ion complexes enhance magnetic resonance imaging for organ and tumor visualization. Studies show iron and gadolinium contrast agents can assess gastrointestinal, brain, and kidney functions, and detect heart and blood-brain-barrier issues.

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    Area of Science:

    • Medical imaging
    • Biochemistry
    • Pharmacology

    Background:

    • Routine magnetic resonance imaging (MRI) can be supplemented by targeted contrast agents.
    • Paramagnetic ion complexes offer tissue-, organ-, or tumor-specific properties.
    • Assessing organ perfusion and function can be improved with advanced imaging techniques.

    Purpose of the Study:

    • To evaluate the utility of paramagnetic ion complexes as contrast agents in magnetic resonance imaging.
    • To explore the diagnostic potential of specific iron and gadolinium-based contrast agents.
    • To assess the effectiveness of these agents in evaluating organ function and detecting abnormalities.

    Main Methods:

    • Studies conducted in both animal models and human subjects.
    • Administration of dilute iron solutions for gastrointestinal tract contrast enhancement.

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  • Administration of ferrioxamine B to assess blood-brain-barrier defects and renal function.
  • Administration of gadolinium-DTPA for lesion enhancement and blood-brain-barrier integrity assessment.

    • Main Results:

    • Dilute iron solutions showed promise for gastrointestinal contrast enhancement.
    • Ferrioxamine B facilitated identification of focal blood-brain-barrier defects and assessed renal excretory function.
    • Gadolinium-DTPA effectively enhanced various lesions and detected blood-brain-barrier breakdown.
    • Gadolinium-DTPA delineated functioning myocardium during acute ischemia.

    Conclusions:

    • Paramagnetic ion complexes represent a valuable supplement to routine MRI.
    • Specific agents like ferrioxamine B and gadolinium-DTPA demonstrate significant diagnostic capabilities.
    • These contrast agents can improve the assessment of organ perfusion, function, and the detection of specific pathologies.