Related Experiment Video

Updated: Aug 8, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

Retrogenic expression of receptors for growth factors in neoplasia

M Cikes

    Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
    |January 1, 1984
    PubMed

    Insights

    Hormone-dependent tumors exhibit altered hormone receptor expression, leading to increased sensitivity to growth factors. This inappropriate receptor expression in cancer cells contributes to tumor development and apparent autonomy.

    Area of Science:

    • Oncology
    • Endocrinology
    • Molecular Biology

    Background:

    • Hormone-dependent tumors show reduced reliance on growth hormones compared to normal tissues.
    • Cancer cells display inappropriate expression of hormone receptors, increasing sensitivity to growth factors.

    Purpose of the Study:

    • To investigate the role of aberrant hormone receptor expression in hormone-dependent tumor development.
    • To understand how ectopic receptor expression contributes to cancer cell autonomy and sensitivity.

    Main Methods:

    • Analysis of hormone receptor expression patterns in tumor cells versus normal tissues.
    • Comparative studies on the hormonal sensitivity of cancer cells and their normal counterparts.

    Main Results:

    • Cancer cells exhibit inappropriate expression of hormone receptors, differing from normal tissue.
    • Ectopic expression of multiple hormone and growth factor receptors confers apparent autonomy to cancer cells.
    • Some cancer cells mimic the hormonal sensitivity and receptor profile of earlier developmental stages.

    Conclusions:

    • Aberrant hormone receptor expression is a key factor in the development and behavior of hormone-dependent tumors.
    • The findings highlight potential therapeutic targets related to hormone receptor signaling in cancer.

    More Related Videos

    Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells11:42

    Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

    Published on: April 7, 2017

    Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

    Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

    Published on: October 27, 2020

    Related Concept Videos

    Enzyme-linked Receptors01:00

    Enzyme-linked Receptors

    Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
    Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
    Mitogens and the Cell Cycle02:38

    Mitogens and the Cell Cycle

    Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
    Cancer-Critical Genes I: Proto-oncogenes01:33

    Cancer-Critical Genes I: Proto-oncogenes

    Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
    When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
    Such genes that act...
    mTOR Signaling and Cancer Progression03:03

    mTOR Signaling and Cancer Progression

    The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
    The mTOR pathway or the...
    Receptor Downregulation in MVBs01:15

    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
    Cancer-Critical Genes I: Proto-oncogenes01:33

    Cancer-Critical Genes I: Proto-oncogenes

    Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
    When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
    Such genes that act...