Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Phialophora parasitica, an emerging pathogen.

I Weitzman, M A Gordon, R W Henderson

|January 1, 1984

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2020

Same author

Increased intracellular survival of Salmonella Typhimurium ST313 in HIV-1-infected primary human macrophages is not associated with Salmonella hijacking the HIV compartment.

Biology of the cell·2020

Same author

Nonspecific effects of oral vaccination with live-attenuated <i>Salmonella</i> Typhi strain Ty21a.

Science advances·2019

Same author

Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2013

Same author

Review article: the aetiology, investigation and management of diarrhoea in the HIV-positive patient.

Alimentary pharmacology & therapeutics·2011

Same author

Family practice residency: was it worth it?

Canadian family physician Medecin de famille canadien·2011

This study characterized Phialophora parasitica isolates, finding variations in traits and antifungal responses. Most isolates were sensitive to amphotericin B and miconazole but resistant to 5-fluorocytosine and ketoconazole.

Area of Science:

Medical Mycology
Clinical Microbiology

Background:

Phialophora parasitica is a fungal species with clinical and environmental relevance.
Accurate identification and understanding antifungal susceptibility are crucial for effective treatment.

Purpose of the Study:

To compare morphologic and physiologic characteristics of Phialophora parasitica isolates.
To evaluate the antifungal susceptibility profiles of these isolates.

Main Methods:

Monoconidial cultures from 12 clinical and environmental isolates were analyzed.
Morphologic, physiologic (urease, casein, starch, tyrosine, gelatin hydrolysis), and temperature growth profiles were assessed.
Antifungal susceptibility testing was performed using minimum inhibitory concentrations (MICs).

Related Experiment Videos

Main Results:

Isolates exhibited variability in distinguishing characteristics across different media.
All isolates were urease-positive, hydrolyzed casein and starch, and most decomposed tyrosine.
Optimal growth occurred at 23 and 37 degrees C; no growth at 40 degrees C.
Most isolates showed low sensitivity to amphotericin B and miconazole, and resistance to 5-fluorocytosine and ketoconazole.

Conclusions:

Phialophora parasitica isolates display diverse characteristics and antifungal responses.
Amphotericin B and miconazole show potential therapeutic value, while 5-fluorocytosine and ketoconazole are less effective.
Further comparative studies with related Phialophora species are warranted.