Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calmodulin and malignant hyperpyrexia.

L A Marjanen, S P Collins, M A Denborough

    Biochemical Medicine
    |October 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Calmodulin regulates cellular calcium (Ca2+). This study found no calmodulin abnormalities in malignant hyperpyrexia-susceptible pig muscle, suggesting calmodulin is not involved in this condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Four-year Prostate-specific Antigen Response Rate as a Predictive Measure in Intermediate-risk Prostate Cancer Treated With Ablative Therapies: The SPRAT Analysis.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2021
    Same author

    Ocean acidification effects on fish hearing.

    Proceedings. Biological sciences·2021
    Same author

    A positive, growth-based PAM screen identifies noncanonical motifs recognized by the <i>S. pyogenes</i> Cas9.

    Science advances·2020
    Same author

    Observation of strong nonlinear interactions in parametric down-conversion of X-rays into ultraviolet radiation.

    Nature communications·2019
    Same author

    Selective probing of magnetic order on Tb and Ir sites in stuffed Tb<sub>2</sub>Ir<sub>2</sub>O<sub>7 </sub> using resonant x-ray scattering.

    Journal of physics. Condensed matter : an Institute of Physics journal·2019
    Same author

    Critical fluctuations in the spin-orbit Mott insulator Sr<sub>3</sub>Ir<sub>2</sub>O<sub>7</sub>.

    Journal of physics. Condensed matter : an Institute of Physics journal·2019
    Same journal

    Platelet phenylalanine hydroxylating activity in phenylketonurics and normal controls.

    Biochemical medicine·1985
    Same journal

    Effect of swimming on protein degradation: 3-methylhistidine and creatinine excretion.

    Biochemical medicine·1985
    Same journal

    Lipid peroxidation in liver, plasma, and erythrocytes of rats chronically treated with ethanol.

    Biochemical medicine·1985
    Same journal

    Myoadenylate deaminase deficiency and malignant hyperthermia susceptibility: is there a relationship?

    Biochemical medicine·1985
    Same journal

    Glycolytic and tricarboxylic acid cycle intermediates in dog livers during endotoxic shock.

    Biochemical medicine·1985
    Same journal

    Uptake of proline by brushborder vesicles isolated from human kidney cortex.

    Biochemical medicine·1985
    See all related articles

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Physiology

    Background:

    • Calmodulin (CaM) is a key calcium-binding protein regulating cellular processes.
    • Malignant hyperpyrexia (MH) is a severe pharmacogenetic disorder characterized by disturbed myoplasmic calcium (Ca2+) levels.
    • A potential role for CaM in MH pathogenesis has been hypothesized due to CaM's calcium-regulatory functions.

    Purpose of the Study:

    • To investigate the potential involvement of calmodulin in malignant hyperpyrexia (MH).
    • To examine calmodulin activation and its inhibition by trifluoperazine in muscle from MH-susceptible pigs.

    Main Methods:

    • Utilized crude and purified calmodulin preparations from control and MH-susceptible pigs.
    • Assessed calmodulin activation by phosphodiesterase.

    Related Experiment Videos

  • Studied the effect of trifluoperazine on calmodulin activation.

    • Main Results:

    • No abnormalities were detected in the activation pattern of calmodulin from MH-susceptible pig muscle.
    • Trifluoperazine-induced inhibition of calmodulin activation showed no differences between control and MH-susceptible groups.
    • These findings indicate normal calmodulin function in the context of MH susceptibility.

    Conclusions:

    • Calmodulin function appears to be normal in MH-susceptible porcine muscle.
    • The study does not support a role for calmodulin in the pathophysiology of malignant hyperpyrexia.
    • Further research may be needed to elucidate the precise mechanisms underlying MH.