[The antioxidant system of transferrin-ceruloplasmin in experimental hypercholesterolemia]

Experimental rabbits were fed cholesterol during three months. The amount of cholesterol, lipid peroxidation products, and the ratio of the ESR signal of ceruloplasmin to one of transferrins (Cp/Tf) increased in the serum of experimental rabbits as compared with the control group animals. The animals with the high Cp/Tf ratio had a low cholesterol level and a low concentration of lipid peroxidation products in the serum. The increased Cp/Tf ratio in the serum may be explained by the elevation of the Cp and Tf antioxidant activity. The rise of the antioxidant activity may be referred to the defence reaction of the body toward hypercholesterolemia.