Partial peripheral resistance to thyroid hormones, a post-receptor defect?

Nuclear receptor for T3 in circulating lymphocytes and cultured fibroblasts from patients with partial resistance to thyroid hormones have in the majority of the cases a normal binding affinity and a normal maximal binding capacity. This would mean that in the majority of the cases the receptors do not show any major abnormalities and that probably the mechanism for the resistance may be sought for in postreceptor events, in the transcriptional or translational events. In a few cases there has been evidence for an abnormal receptor or for the lack of an receptor.