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Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids.

E J Van Scott, R J Yu

    Journal of the American Academy of Dermatology
    |November 1, 1984
    PubMed
    Summary
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    Hyperkeratinization, a key factor in skin disorders, stems from increased corneocyte cohesion. Modifying keratinization through agents like retinoids or alpha hydroxy acids offers therapeutic potential for skin conditions.

    Area of Science:

    • Dermatology
    • Cell Biology
    • Biochemistry

    Background:

    • Hyperkeratinization is a fundamental process in numerous skin disorders.
    • It often results from reduced skin cell shedding (desquamation) due to heightened corneocyte cohesion.
    • Corneocyte cohesion strength is directly linked to intercellular bonding.

    Purpose of the Study:

    • To explore the factors influencing corneocyte cohesion.
    • To understand how various agents affect intercellular bonding and keratinization.
    • To identify potential therapeutic targets for skin disorders involving hyperkeratinization.

    Main Methods:

    • The study reviews existing literature on hyperkeratinization and corneocyte cohesion.
    • It analyzes the impact of water, dehydration, and specific chemical agents on intercellular bonding.

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  • Investigates the role of vitamin A and its derivatives in keratinization processes.

    • Main Results:

    • Intercellular bonding is weakened by water and diminished by retinoids and alpha hydroxy acids (AHAs).
    • Conversely, dehydration, vitamin A deficiency, and certain alpha acetoxy acids (AAAs) strengthen intercellular bonding.
    • These findings highlight the complex regulation of corneocyte cohesion.

    Conclusions:

    • Agents that modulate keratinization hold significant therapeutic promise.
    • Understanding the mechanisms of corneocyte cohesion is crucial for treating hyperkeratinization-related skin disorders.
    • Targeting intercellular bonding offers a potential strategy for dermatological therapies.