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Related Experiment Videos

Enhanced sensitivity to digoxin in dystrophic mice.

K Saito, H Ohkura, T Kashima

    Japanese Heart Journal
    |September 1, 1984
    PubMed
    Summary

    Dystrophic mice exhibit heightened sensitivity to digoxin, a heart medication. This increased sensitivity is not linked to altered digoxin levels or potassium in heart muscle, but rather to longer action potential durations.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Genetics

    Background:

    • Digoxin is a cardiac glycoside used to treat heart conditions.
    • Duchenne muscular dystrophy (DMD) is a genetic disorder affecting muscle function.
    • The cardiac effects of digoxin in dystrophic models require further investigation.

    Purpose of the Study:

    • To investigate the impact of digoxin on myocardial potassium content and cardiac action potentials in dystrophic mice.
    • To determine the underlying mechanisms of potential digoxin hypersensitivity in this model.

    Main Methods:

    • Intraperitoneal injection and ex vivo perfusion of digoxin in dystrophic (dy/dy) and normal mice.
    • Measurement of myocardial digoxin and potassium concentrations.
    • Electrophysiological recordings of left ventricular papillary muscle action potentials.

    Main Results:

    • Dystrophic mice showed significantly longer action potential durations (APD) compared to normal mice.
    • Intraperitoneal digoxin injection was lethal to all dystrophic mice at a sub-lethal dose for normal mice.
    • Digoxin perfusion shortened APD and induced arrhythmias in dystrophic mice, but not in normal mice.
    • Myocardial digoxin and potassium levels were similar between dystrophic and normal mice post-injection.

    Conclusions:

    • Dystrophic mice display increased sensitivity to digoxin.
    • This hypersensitivity is not attributable to altered myocardial digoxin uptake or potassium content.
    • The prolonged APD in dystrophic mice may contribute to their heightened susceptibility to digoxin toxicity.

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