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Cyclic nucleotide changes and contractility in the rat anococcygeus muscle
Research Communications in Chemical Pathology and Pharmacology
|November 1, 1984
Abstract:
The rat anococcygeus muscle can be activated by three different agonists, NA, ACh and KCl, each of these displaying a different degree of pharmacomechanical coupling. Investigation of cyclic nucleotide changes in the muscles when activated showed that changes in cAMP/cGMP ratio parallel changes in contractility. However, the cyclic nucleotide changes seem incidental to the process of contraction, rather than causally related to it.