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Cefmenoxime: in vitro activity.

J M Stamm

    The American Journal of Medicine
    |December 21, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Cefmenoxime, a new cephalosporin antibiotic, shows potent in vitro activity against many Gram-negative and Gram-positive bacteria. It is particularly effective against common respiratory and urinary tract pathogens.

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    Antimicrobial activity of cefmenoxime (SCE-1365).

    Antimicrobial agents and chemotherapy·1981

    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Cefmenoxime (SCE-1365 or A-50912) is a novel semisynthetic cephalosporin antibiotic.
    • Antimicrobial resistance necessitates the development of new therapeutic agents.

    Purpose of the Study:

    • To evaluate the in vitro antimicrobial activity of cefmenoxime.
    • To determine the spectrum of activity and potency against a wide range of clinically relevant bacteria.

    Main Methods:

    • A multiclinic study involving 1,234 bacterial isolates.
    • Determination of minimum inhibitory concentrations (MICs) for cefmenoxime.
    • Calculation of MIC90 (concentration inhibiting 90% of strains) and MIC50 (concentration inhibiting 50% of strains).

    Main Results:

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    • Cefmenoxime demonstrated potent activity against Enterobacteriaceae (MIC90: 0.12–8 µg/ml).
    • High efficacy was observed against Streptococcus pneumoniae (MIC90: 0.015 µg/ml), Streptococcus pyogenes (MIC90: 0.06 µg/ml), Neisseria gonorrhoeae, and Hemophilus influenzae.
    • Moderate activity was noted against Staphylococcus aureus (MIC90: 4 µg/ml), with less susceptibility in Group D streptococci.
    • Lower activity was observed against Pseudomonas aeruginosa, Acinetobacter species, and Bacteroides fragilis (MIC50: 16 µg/ml).

    Conclusions:

    • Cefmenoxime exhibits broad-spectrum in vitro activity, with notable potency against key Gram-negative and Gram-positive pathogens.
    • Its efficacy against common respiratory and genitourinary pathogens suggests potential clinical utility.
    • Further investigation into its pharmacokinetic and clinical efficacy is warranted.