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Auditory brainstem responses in pervasive developmental disorders.

J M Rumsey, A M Grimes, A M Pikus

    Biological Psychiatry
    |October 1, 1984
    PubMed
    Summary
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    This study found normal auditory brainstem responses (ABRs) in most individuals with pervasive developmental disorders (PDDs), including autism. Previous findings of prolonged neural transmission times in autism were not replicated.

    Area of Science:

    • Neuroscience
    • Developmental Psychology
    • Audiology

    Background:

    • Previous research suggested central nervous system (CNS) dysfunction in autism, indicated by prolonged auditory brainstem responses (ABRs).
    • Auditory brainstem responses (ABRs) are electrophysiological measures assessing neural pathway integrity from the cochlea to the midbrain.

    Purpose of the Study:

    • To investigate auditory brainstem response (ABR) transmission times in individuals with pervasive developmental disorders (PDDs), including autism.
    • To determine if prolonged ABRs, indicative of CNS dysfunction, are prevalent in PDDs as previously reported.

    Main Methods:

    • Auditory brainstem responses (ABRs) were measured in 25 individuals with PDDs (including autism) and 25 age- and sex-matched controls.
    • Subjects underwent thorough audiometric and neurological evaluations.

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  • Artifact control measures were implemented to ensure reliable ABR data collection.

    • Main Results:

    • The majority of PDD subjects exhibited normal ABR transmission times.
    • Only one PDD subject and one control subject showed prolonged transmission times.
    • Shortened transmission times were observed in four PDD subjects.

    Conclusions:

    • The study did not replicate previous findings of a high incidence of prolonged ABRs in autistic individuals.
    • Most individuals with PDDs demonstrate normal ABRs, suggesting CNS dysfunction at the brainstem level is not a universal characteristic.
    • Discrepancies with prior research highlight the need for further investigation into ABR findings in autism spectrum disorder.