Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haemosiderin and tissue damage.

M P Weir, J F Gibson, T J Peters

    Cell Biochemistry and Function
    |October 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Haemosiderin, an iron-storage compound in iron overload, is formed from ferritin. Its chemical makeup and role in iron cytotoxicity require further investigation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Revealing microscale bulk structures in polymer-carbon nanocomposites using spin-echo SANS.

    Soft matter·2024
    Same author

    Distortion of Chain Conformation and Reduced Entanglement in Polymer-Graphene Oxide Nanocomposites.

    ACS macro letters·2022
    Same author

    Prospectus: towards the development of high-fidelity models of wall turbulence at large Reynolds number.

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2017
    Same author

    The mRNA landscape at yeast translation initiation sites.

    Bioinformatics (Oxford, England)·2010
    Same author

    Mechanically driven wrinkling instability in thin film polymer bilayers.

    Physical review. E, Statistical, nonlinear, and soft matter physics·2007
    Same author

    Proteomics: quantitative and physical mapping of cellular proteins.

    Trends in biotechnology·1999
    Same journal

    Redox Metabolism and Metabolic Vulnerabilities in Diabetes-Driven Pancreatic Cancer: Targeting System Xc<sup>-</sup>, mTORC1, and Disulfidptosis as Therapeutic Strategy.

    Cell biochemistry and function·2026
    Same journal

    Identification of PRKCB, NLRC4, and TNFSF10 as Key Regulators of the Lipid Metabolism-Autophagy Network in Atherosclerosis.

    Cell biochemistry and function·2026
    Same journal

    Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits.

    Cell biochemistry and function·2026
    Same journal

    The Role of RNA Helicase DHX33 in Tumorigenesis.

    Cell biochemistry and function·2026
    Same journal

    Oral Calcium Supplements With L-Proline and Sodium Zinc Chlorophyllin Preserve Elevated Transepithelial Calcium Transport in Spontaneously Hypertensive Rats.

    Cell biochemistry and function·2026
    Same journal

    Exosomal MicroRNA-424-5p From Polycystic Ovary Syndrome Follicular Fluid Attenuates Ovarian Inflammation via Targeting the Fibroblast Growth Factor 2/Fibroblast Growth Factor Receptor 1 Axis.

    Cell biochemistry and function·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Pathology
    • Materials Science

    Background:

    • Haemosiderin is the primary iron-storage compound in iron overload disorders like idiopathic haemochromatosis and thalassemia.
    • It is predominantly found in conditions with high iron levels.

    Purpose of the Study:

    • To investigate the chemical composition and structure of haemosiderin.
    • To understand the formation pathway of haemosiderin from ferritin.
    • To explore the potential role of haemosiderin in iron-induced cytotoxicity.

    Main Methods:

    • Analysis of haemosiderin structure and composition.
    • Biochemical assays to determine constituent elements and compounds.
    • Investigating the transformation process from ferritin to haemosiderin.

    Related Experiment Videos

    Main Results:

    • Haemosiderin comprises aggregated FeOOH cores with incomplete protein shells, likely originating from ferritin degradation.
    • Chemical degradation of ferritin cores occurs during haemosiderin formation.
    • Phosphate, magnesium, and lipids are other identified components adsorbed to the core surface.

    Conclusions:

    • Haemosiderin is a complex iron-storage material derived from ferritin.
    • Its unique structure and composition suggest a potential role in iron cytotoxicity.
    • Further research into haemosiderin's chemistry and biochemistry is warranted.