Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxic-ischemic encephalopathy and plasma beta-endorphin.

K Sankaran, K W Hindmarsh, V G Watson

    Developmental Pharmacology and Therapeutics
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Narcotics and sedatives use in the mechanical ventilation in preterm infants: Predictors and outcome.

    Journal of neonatal-perinatal medicine·2019
    Same author

    Influence of Branching on the Conformational Space: Case Study of Tri- sec-butyl Phosphate Using Matrix Isolation Infrared Spectroscopy and DFT Computations.

    The journal of physical chemistry. A·2018
    Same author

    13-Docosenamide release by bacteria in response to glucose during growth-fluorescein quenching and clinical application.

    Applied microbiology and biotechnology·2018
    Same author

    Uranyl tris nitrato as a luminescent probe for trace water detection in acetonitrile.

    Luminescence : the journal of biological and chemical luminescence·2018
    Same author

    Nitrogen: A New Class of π-Bonding Partner in Hetero π-Stacking Interaction.

    The journal of physical chemistry. A·2017
    Same author

    Experience information as the basis of mind: Evidence from human decision making.

    Progress in biophysics and molecular biology·2017

    Hypoxic-ischemic encephalopathy with ongoing hypoxemia significantly elevates plasma beta-endorphin (beta-ED) levels in newborns. This suggests hypoxemia is a key factor in beta-ED release during neonatal brain injury.

    Area of Science:

    • Neonatal Medicine
    • Neuroscience
    • Endocrinology

    Background:

    • Hypoxic-ischemic encephalopathy (HIE) is a serious neonatal condition.
    • The role of beta-endorphin (beta-ED) in HIE is not fully understood.
    • Associated conditions like hypoxemia may influence beta-ED levels.

    Purpose of the Study:

    • To investigate plasma beta-endorphin (beta-ED) concentrations in term infants with HIE.
    • To determine if HIE itself or associated pathologic conditions increase beta-ED.
    • To assess the impact of ongoing hypoxemia on beta-ED levels.

    Main Methods:

    • Plasma beta-ED was measured in three groups of term infants: controls, HIE with ongoing hypoxemia, and HIE with normoxemia post-resuscitation.
    • Infants were assessed for clinical and neurological signs of HIE and monitored for oxygen levels.

    Related Experiment Videos

  • Statistical comparisons were made between the groups.

    • Main Results:

    • Group 2 (HIE with ongoing hypoxemia) showed significantly higher plasma beta-ED concentrations (103 pg/ml) compared to controls (19 pg/ml) and Group 3 (HIE, normoxemic) (25 pg/ml).
    • Infants in Group 2 experienced conditions like meconium aspiration and persistent fetal circulation.
    • Group 3 infants were normoxemic after resuscitation.

    Conclusions:

    • Ongoing hypoxemia in term infants with HIE is associated with significantly elevated plasma beta-endorphin levels.
    • Hypoxemia appears to be a potent stimulus for beta-ED release in this population.
    • These findings highlight the complex interplay between oxygen status and neuroendocrine responses in neonatal brain injury.