Granular cell tumor of the lower lid: histological and immunohistochemical studies

Histological and immunohistochemical studies of a granular cell tumor involving the lower lid are described. Histological examination showed it to have typical features of a granular cell tumor. Nervous-system-specific protein (S-100 protein) was detected in both the nuclei and cytoplasm of granular cells using the peroxidase-anti-peroxidase method. This result further supports the concept of the neurogenic origin of granular cell tumors.