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Subcutaneous phaeohyphomycosis caused by Exophiala spinifera.

A A Padhye, W Kaplan, M A Neuman

    Sabouraudia
    |January 1, 1984
    PubMed
    Summary

    This case report details the second known human subcutaneous infection caused by Exophiala spinifera in the US. Prompt diagnosis and antifungal treatment led to a successful recovery.

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    Area of Science:

    • Mycology
    • Infectious Diseases
    • Dermatology

    Background:

    • Subcutaneous fungal infections are uncommon, particularly those caused by dematiaceous fungi.
    • Exophiala spinifera is a fungus typically found in soil and decaying plant material.
    • Human infections are rare, with limited documented cases.

    Observation:

    • A case of subcutaneous infection in a US patient is presented.
    • Diagnosis was confirmed through morphological analysis of fungal elements in tissue biopsy and cultured isolates.
    • The patient presented with a subcutaneous infection.

    Findings:

    • Morphological identification confirmed the causative agent as Exophiala spinifera.
    • Treatment involved a combination of ketoconazole and 5-fluorocytosine.
    • The patient achieved a complete cure following the prescribed antifungal therapy.

    Implications:

    • This case expands the geographic and clinical spectrum of Exophiala spinifera infections in humans.
    • Highlights the importance of accurate mycological diagnosis for effective treatment of rare fungal infections.
    • Suggests ketoconazole and 5-fluorocytosine as a viable treatment regimen for Exophiala spinifera subcutaneous infections.

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