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[Infantile spasms in children under 1-year-old]

L T Zhurba, O V Timonina, I A Koroleva

    Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
    |January 1, 1984
    PubMed

    Insights

    Early corticosteroid therapy, including ACTH, synacthen, and hydrocortisone, is effective for infantile spasms. This treatment shows promise for both idiopathic cases and those with pre-existing neurological impairments.

    Area of Science:

    • Pediatric Neurology
    • Endocrinology

    Background:

    • Infantile spasms (IS) are a severe epilepsy syndrome in infants.
    • Early diagnosis and treatment are crucial for optimal outcomes.
    • Corticosteroids are a primary treatment modality for IS.

    Purpose of the Study:

    • To evaluate the efficacy of corticosteroid therapy in infantile spasms.
    • To compare treatment outcomes in "idiopathic" IS versus those with pre-existing neurological damage.
    • To analyze the clinical presentation and treatment response over time.

    Main Methods:

    • Observational study of 72 infants (10 days to 12 months) with infantile spasms (1977-1982).
    • Clinical assessment, echoencephalography, diaphanoscopy, cranial roentgenography, ophthalmoscopy, and electroencephalography (EEG) were utilized.
    • Patients were categorized into "idiopathic" and those with prior nervous system insults.

    Main Results:

    • Corticosteroid therapy (ACTH, synacthen, hydrocortisone) demonstrated effectiveness when initiated early.
    • Treatment outcomes were analyzed before, during, and after therapy.
    • The study describes the clinical picture of infantile spasms extensively.

    Conclusions:

    • Early institution of hormonal therapy is key to successful treatment of infantile spasms.
    • Corticosteroids are effective in managing infantile spasms, regardless of underlying etiology.
    • Further analysis of hormonal drug mechanisms is warranted.

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