Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GABA, taurine and hypotaurine in developing mouse brain.

P Kontro, K M Marnela, S S Oja

    Acta Physiologica Scandinavica. Supplementum
    |January 1, 1984
    PubMed
    Summary

    This study tracked the brain levels and uptake of taurine, hypotaurine, and GABA in developing mice. Findings show these neuromodulators are active early in postnatal life.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of taurine, hypotaurine and β-alanine uptake in brain synaptosomal preparations from developing and adult mouse.

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
    Same author

    Different in vitro and in vivo profiles of substituted 3-aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABA(B) receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation.

    British journal of pharmacology·2011
    Same author

    Actions of taurine on the GABA-benzodiazepine receptor complex solubilized from rat brain.

    Neurochemistry international·2010
    Same author

    Glutamate release from cerebellar granule cells differentiating in culture: Modulation of the K(+)-stimulated release by inhibitory amino acids.

    Neurochemistry international·2010
    Same author

    Ruthenium red interferes with the tetanus toxin inhibition of potassium-stimulated GABA release from rat cerebral cortex slices.

    Neurochemistry international·2010
    Same author

    Tetanus toxin treatment in vitro inhibits the release of GABA from rat cerebral cortex slices evoked by high K(+) and Na(+)-free media.

    Neurochemistry international·2010

    Area of Science:

    • Neuroscience
    • Developmental Biology

    Background:

    • Taurine and hypotaurine are considered potential neuromodulators.
    • Gamma-aminobutyric acid (GABA) is an established neurotransmitter.
    • Understanding their developmental roles is crucial for brain function.

    Purpose of the Study:

    • To compare the developmental changes in cerebral concentrations and synaptosomal uptake of taurine, hypotaurine, and GABA in mice from birth to 3 months.
    • To investigate the developmental patterns of taurine and hypotaurine in blood serum.
    • To assess the developmental changes in sodium-independent binding of GABA and taurine to synaptic membranes.

    Main Methods:

    • Cerebral concentrations and synaptosomal uptake of taurine, hypotaurine, and GABA were measured in mice from birth to 3 months.
    • Blood serum levels of taurine and hypotaurine were monitored.
    • Sodium-independent binding of GABA and taurine to synaptic membranes was analyzed.

    Main Results:

    • Maximum brain concentrations were reached at different ages: taurine at 1 week, hypotaurine at 3 weeks, and GABA at 4 weeks.
    • Serum hypotaurine peaked in 1-week-old mice, while taurine peaked in the first three weeks.
    • Uptake of all three compounds was high in the first three weeks, then stabilized. GABA binding was highest at 2 weeks, and taurine binding was higher in immature than adult brains.

    Conclusions:

    • Significant developmental alterations in the concentrations, uptake, and binding of GABA, taurine, and hypotaurine were observed.
    • These changes indicate that GABA, taurine, and hypotaurine are functionally active in the brain during early postnatal development.

    Related Experiment Videos