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Related Experiment Videos

Intranuclear inclusions in rat piriform cortex: increase with age and preferential location within superficial layer

C A Curcio, N A McNelly, J W Hinds

    The Anatomical Record
    |December 1, 1984
    PubMed
    Summary

    Intranuclear inclusions, appearing as filamentous lattices, were found in rat piriform cortex neurons. Their occurrence significantly increases with age, particularly after 18 months, suggesting a link to neuronal activity.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Aging Research

    Background:

    • Intranuclear inclusions, specifically filamentous lattices, are observed in neurons.
    • These inclusions have been previously documented in scientific literature.
    • The piriform cortex is known for its high level of electrical activity.

    Purpose of the Study:

    • To investigate the occurrence and distribution of intranuclear inclusions in rat piriform cortex neurons.
    • To determine the relationship between the presence of these inclusions and the age of the rats.
    • To explore potential correlations between intranuclear inclusions and neuronal activity.

    Main Methods:

    • Microscopic examination of layer II neurons in the rat piriform cortex.
    • Quantification of intranuclear inclusions based on age.

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  • Analysis of the spatial distribution of inclusions within layer II.

    • Main Results:

    • Intranuclear inclusions in a filamentous lattice form were identified in layer II piriform cortex neurons.
    • A significant fourfold increase in the frequency of these inclusions was observed between 3 and 33 months of age.
    • The incidence of inclusions was highest in the superficial third of layer II and increased markedly after 18 months of age.

    Conclusions:

    • The presence and age-dependent increase of intranuclear lattices in piriform cortex neurons suggest a cumulative effect.
    • These findings may be linked to the high electrical activity characteristic of the piriform cortex.
    • Further research is warranted to elucidate the precise mechanisms and functional implications of these intranuclear inclusions.