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Gene Families

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...

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Related Experiment Video

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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Characterization of two rat globin cDNA clones.

R Crkvenjakov, M Bucan, M Konstantinovic

|January 1, 1984

Summary

Researchers studied the rat globin gene system, analyzing cloned alpha and beta globin sequences. This work provides valuable tools for understanding globin gene regulation and variability in rats.

Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

The rat globin gene system comprises seven genes across two families, offering a model for coordinated gene regulation.
Understanding globin gene expression is crucial for hematological research.

Purpose of the Study:

To construct a rat reticulocyte complementary DNA (cDNA) library.
To analyze specific globin gene clones for structural and functional insights.
To investigate the variability of rat globin chains through amino acid sequence analysis.

Main Methods:

Construction of a rat reticulocyte cDNA library.
Detailed analysis of two complementary DNA (cDNA) clones, designated pBRrg 5 and pBRrg X.
Deduction of amino acid sequences from cloned globin complementary DNA (cDNA).

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Main Results:

Successfully constructed a rat reticulocyte cDNA library.
Identified and characterized two clones: pBRrg 5 containing alpha-type globin sequence and pBRrg X containing beta-type globin sequence.
Deduced amino acid sequences revealed insights into rat globin chain variability.

Conclusions:

The cloned rat globin cDNAs serve as effective probes for studying globin gene structure and function.
This research enhances the understanding of coordinated gene regulation within the rat globin gene system.
The deduced amino acid sequences contribute to the knowledge of globin chain diversity.