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[Clinical evaluation of ceftriaxone in children]
Insights
Ceftriaxone (CTRX) demonstrated excellent clinical efficacy and a 100% efficacy rate in treating bacterial infections, including urinary tract infections. This study found no adverse effects requiring treatment discontinuation, highlighting its safety profile.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Medicine
Background:
- Ceftriaxone (CTRX) is a third-generation cephalosporin antibiotic.
- Evaluation of novel antibiotics is crucial for combating bacterial infections.
Abstract:
Fundamental and clinical evaluation on ceftriaxone (Ro 13-9904, CTRX) was performed and the following results were obtained. As to bacteriological efficacy, bacteria were reduced in the case with S. panama bacteremia, while they were eradicated within 2 to 5 days after CTRX administration in 2 cases with acute urinary tract infections and 1 with recurrent urinary tract infection, both caused with E. coli, and in 1 with acute urinary tract infection with P. mirabilis. The clinical efficacy was excellent in 2 cases and good in 3, the efficacy rate being 100%. No side effects were observed to require the withdrawal of CTRX.