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[Clinical evaluation of ceftriaxone in the pediatric field]
The Japanese Journal of Antibiotics
|November 1, 1984
Insights
Ceftriaxone demonstrated potent antibacterial activity, comparable or superior to cefotaxime against clinical isolates. Clinical trials in children showed satisfactory results with minimal adverse effects like eosinophilia.
Area of Science:
- Microbiology
- Pharmacology
- Pediatrics
Context:
- Antibiotic resistance is a growing global health concern, necessitating the evaluation of new antimicrobial agents.
- Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity.
- Clinical efficacy and safety data are crucial for establishing appropriate therapeutic uses.
Purpose:
- To assess the in vitro antibacterial activity of ceftriaxone against clinical isolates.
- To evaluate the clinical efficacy and safety of ceftriaxone in pediatric patients.
- To compare the antibacterial profile of ceftriaxone with cefotaxime.
Summary:
- Ceftriaxone exhibited antibacterial activity equal to or greater than cefotaxime against tested clinical isolates.
- Clinical evaluation in 10 pediatric patients (6 months to 10.5 years) yielded largely satisfactory outcomes.
- Bacterial eradication was achieved in 75% (3 out of 4) of evaluable strains.
- Adverse reactions were minimal, with eosinophilia noted in only one case.
Impact:
- This study supports the use of ceftriaxone as an effective antibiotic option in pediatric infectious diseases.
- Findings contribute to the understanding of ceftriaxone's therapeutic potential and safety profile in children.
- The data may inform clinical guidelines for antibiotic selection in pediatric settings.
Abstract:
Ceftriaxone CTRX was evaluated about its antibacterial activity against clinical isolates at our department and tried clinically in 10 children of 6 months to 10 years and 6 months of age. The antibacterial activity was equal to cefotaxime or higher while the clinical results were almost satisfactory. Three out of 4 strains were eradicated (75%). As to the adverse reaction, eosinophilia was observed only in 1 case.