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[Evaluation on ceftriaxone in the pediatric field].

S Nakazawa, H Satoh, K Niino

    The Japanese Journal of Antibiotics
    |November 1, 1984
    PubMed
    Summary

    Ceftriaxone (CTRX) demonstrates significant efficacy in pediatric infections, including pertussis and meningitis, with favorable pharmacokinetics and minimal adverse effects. Further studies may be needed for Salmonella infections.

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    Area of Science:

    • Pediatric infectious diseases
    • Pharmacology and pharmacokinetics
    • Antibacterial agents

    Context:

    • Ceftriaxone (CTRX) is a third-generation cephalosporin antibiotic.
    • Pediatric infections pose a significant global health challenge.
    • Evaluating novel antibiotic efficacy and safety in children is crucial.

    Purpose:

    • To assess the fundamental and clinical efficacy of ceftriaxone (CTRX) in pediatric patients.
    • To determine the pharmacokinetic profile of CTRX following intravenous administration.
    • To evaluate the safety and tolerability of CTRX in children.

    Summary:

    • Ceftriaxone (CTRX) exhibited potent in vitro activity against Bordetella pertussis (MIC ≤ 0.05 μg/ml).
    • Intravenous drip infusion resulted in peak plasma concentrations of 45.3–137 μg/ml, with effective levels maintained for up to 12 hours and a half-life exceeding 6 hours.

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  • CTRX showed high clinical efficacy (100%) in treating acute pediatric infections, including respiratory tract infections and urinary tract infections caused by resistant E. coli.
  • Favorable penetration into cerebrospinal fluid was observed in S. pneumoniae meningitis, leading to rapid clinical improvement.
  • While effective against most bacteria, CTRX showed relapses in some Salmonella infections, suggesting a need for dose adjustment.

    • Impact:

    • Ceftriaxone (CTRX) is a valuable therapeutic option for various acute pediatric infections.
    • The drug's favorable pharmacokinetic profile and safety suggest its utility in pediatric clinical practice.
    • Findings support the use of CTRX in managing S. pneumoniae meningitis and certain respiratory and urinary tract infections.
    • Further investigation is warranted for optimizing CTRX treatment in Salmonella infections.