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Related Experiment Videos

Nerve fibers in trabecular meshwork surface.

A Sugita, H Yoshioka

    Japanese Journal of Ophthalmology
    |January 1, 1984
    PubMed
    Summary

    Japanese monkey eyes reveal varicose nerve fibers in the trabecular meshwork. These adrenergic nerve fibers may influence aqueous humor outflow by releasing noradrenaline.

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    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Microscopy

    Background:

    • The trabecular meshwork is crucial for regulating intraocular pressure.
    • Innervation of the trabecular meshwork is not fully understood.
    • Adrenergic signaling plays a role in ocular physiology.

    Purpose of the Study:

    • To investigate the presence and morphology of nerve fibers in the Japanese monkey trabecular meshwork.
    • To identify the type of nerve fibers present using specific markers.
    • To explore the potential role of these nerves in aqueous humor dynamics.

    Main Methods:

    • Scanning electron microscopy (SEM) was used to visualize the trabecular meshwork surface.
    • Ultrastructural analysis was performed.
    • 5-hydroxydopamine pretreatment was utilized to identify adrenergic nerve fibers.

    Main Results:

    • Varicose nerve fibers were observed on the anterior surface and within the intertrabecular spaces.
    • These fibers formed a loose-meshed plexus.
    • Adrenergic nerve fibers were identified, often terminating as free endings near endothelial cells.

    Conclusions:

    • The Japanese monkey trabecular meshwork is innervated by adrenergic nerve fibers.
    • These nerves likely release noradrenaline into the aqueous humor.
    • The innervation may influence aqueous humor outflow and intraocular pressure regulation.

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