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Changes in serum cyclic nucleotide concentration during open-heart surgery.

G Váczi, J Aranyosi, S M Békássy

    Scandinavian Journal of Thoracic and Cardiovascular Surgery
    |January 1, 1984
    PubMed
    Summary

    Serum cyclic adenosine monophosphate (cAMP) increased in coronary sinus blood after open-heart surgery, while cyclic guanosine monophosphate (cGMP) decreased. Lower cAMP and higher cGMP levels correlated with impaired spontaneous heart recovery after surgery.

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    Area of Science:

    • Cardiology
    • Biochemistry
    • Physiology

    Background:

    • Open-heart surgery often involves myocardial ischemia.
    • Cold cardioplegia is used to protect the heart during surgery.
    • Cyclic nucleotides (cAMP and cGMP) play roles in cellular energy regulation and function.

    Purpose of the Study:

    • To investigate changes in serum cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) concentrations during open-heart surgery with cold cardioplegia.
    • To correlate these changes with spontaneous recovery of heart function post-surgery.

    Main Methods:

    • Blood samples were collected from the radial artery and coronary sinus of 14 patients during open-heart surgery.
    • Samples were analyzed for cAMP and cGMP levels before aortic cross-clamping and at 1 and 9 minutes after declamping.

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  • Statistical analysis was performed to assess significant changes and correlations.

    • Main Results:

    • Serum cAMP levels significantly increased in the coronary sinus after aortic declamping, with no significant arterial changes.
    • Serum cGMP levels significantly decreased after aortic release, followed by an increase at 9 minutes.
    • Patients with spontaneous heart recovery had lower cAMP and higher cGMP levels compared to those without recovery.

    Conclusions:

    • Cold cardioplegia affects myocardial cyclic nucleotide levels during open-heart surgery.
    • Altered cAMP and cGMP dynamics may indicate myocardial sensitivity to hypoxia and energy resource utilization.
    • These findings suggest potential biomarkers for predicting spontaneous cardiac recovery after surgical procedures.