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Synthesis and radiochemical stability of 14C-cefotaxime
Arzneimittel-Forschung
|January 1, 1984
Abstract:
14C-Cefotaxime (14C-HR 756) has been synthesised with the radiolabel in the sidechain aminothiazole ring by a multistep sequence starting from 14C-thiourea. A high specific activity batch (10400 microCi g-1), and a low specific activity batch (57.1 microCi g-1) suitable for intravenous human use were prepared; their purity, and solid-state and aqueous solution stability, are described.