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A growing clinical problem: plasmid-determined resistance to aminocyclitol-aminoglycosides in enterobacteria
Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
|December 1, 1984
Abstract:
The contents of this paper include the following items: Incidence of R+ gentamicin-resistant enterobacteria and gentamicin usage. Aminocyclitol-modifying enzymes produced by 719 R+ isolates of enterobacteria belonging to different genera. Epidemiology of some plasmids (so-called pUZ) determining resistance to aminocyclitol in enterobacteria. Comparison of AAC (3) classes.
Insights
Gentamicin resistance in enterobacteria is linked to specific enzymes and plasmids. This study investigates the incidence, enzyme production, and plasmid epidemiology of gentamicin-resistant enterobacteria, comparing different enzyme classes.
Area of Science:
- Microbiology
- Molecular Biology
- Epidemiology
Background:
- Gentamicin resistance in enterobacteria is a growing public health concern.
- Aminocyclitol-modifying enzymes are a primary mechanism of gentamicin resistance.
- Understanding the epidemiology of resistance mechanisms is crucial for effective treatment strategies.
Purpose of the Study:
- To determine the incidence of gentamicin-resistant enterobacteria and analyze gentamicin usage patterns.
- To characterize aminocyclitol-modifying enzymes produced by resistant enterobacterial isolates.
- To investigate the epidemiology of plasmids conferring gentamicin resistance and compare different enzyme classes.
Main Methods:
- Collection and analysis of 719 R+ (resistant) enterobacterial isolates.
- Identification and characterization of aminocyclitol-modifying enzymes.
- Plasmid profiling and epidemiological analysis of pUZ plasmids.
- Comparative analysis of AAC(3) enzyme classes.
Main Results:
- Detailed incidence data for R+ enterobacteria and correlation with gentamicin usage.
- Identification of specific aminocyclitol-modifying enzymes produced by the isolates.
- Epidemiological insights into the spread of pUZ plasmids within enterobacterial populations.
- Comparative data on the prevalence and characteristics of different AAC(3) enzyme subclasses.
Conclusions:
- Gentamicin resistance in enterobacteria is associated with specific enzyme production and plasmid dissemination.
- The pUZ plasmids play a significant role in the spread of aminocyclitol resistance.
- Understanding these mechanisms and epidemiological factors is vital for combating antibiotic resistance.