Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein C.

C T Esmon

    Progress in Hemostasis and Thrombosis
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    The protein C anticoagulant pathway is crucial for regulating blood clotting. Deficiencies in protein C or protein S can lead to thrombosis, highlighting their importance in preventing blood clots.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Group V secretory phospholipase A2 impairs endothelial protein C receptor-dependent protein C activation and accelerates thrombosis in vivo.

    Journal of thrombosis and haemostasis : JTH·2014
    Same author

    Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells.

    Journal of thrombosis and haemostasis : JTH·2014
    Same author

    Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.

    Journal of thrombosis and haemostasis : JTH·2014
    Same author

    Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis).

    Journal of thrombosis and haemostasis : JTH·2012
    Same author

    Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa.

    Journal of thrombosis and haemostasis : JTH·2012
    Same author

    Influence of endothelial cell protein C receptor on plasma clearance of factor VIIa.

    Journal of thrombosis and haemostasis : JTH·2012
    Same journal

    Platelet IgG: measurement, interpretation, and clinical significance.

    Progress in hemostasis and thrombosis·1991
    Same journal

    Essential thrombocythemia.

    Progress in hemostasis and thrombosis·1991
    Same journal

    The lipoprotein-associated coagulation inhibitor.

    Progress in hemostasis and thrombosis·1991
    Same journal

    Fibrinogen and factor VII as risk factors in vascular disease.

    Progress in hemostasis and thrombosis·1991
    Same journal

    Molecular biology of the hemophilias.

    Progress in hemostasis and thrombosis·1991
    Same journal

    The platelet glycoprotein Ib-IX complex.

    Progress in hemostasis and thrombosis·1991
    See all related articles

    Area of Science:

    • Biochemistry
    • Hematology
    • Molecular Biology

    Background:

    • The protein C anticoagulant pathway is a key regulator of coagulation.
    • Protein C deficiency is linked to thrombotic tendencies, emphasizing its critical role.
    • The complexity of this regulatory system is increasingly being understood.

    Purpose of the Study:

    • To explore the regulatory mechanisms of the protein C anticoagulant pathway.
    • To investigate the roles of thrombomodulin and protein S in coagulation.
    • To identify potential therapeutic applications of protein C and thrombomodulin.

    Main Methods:

    • Analysis of protein C activation at the endothelial cell surface.
    • Examination of the dependence of activated protein C on protein S.

    Related Experiment Videos

  • Investigation of the interaction between protein S and C4BP (complement factor H-binding protein).

    • Main Results:

    • Thrombin activation of protein C requires thrombomodulin and a specific binding site.
    • Activated protein C's anticoagulant activity is highly dependent on protein S.
    • Protein S interacts with C4BP, suggesting a link between coagulation and complement systems.

    Conclusions:

    • Deficiencies in thrombomodulin or protein S may contribute to thrombosis.
    • Protein C and thrombomodulin show potential as therapeutic agents.
    • Further research is needed to elucidate the biochemical mechanisms of protein C regulation and function.