Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Leukotrienes and the lung].

A G Leitch

    Revue Des Maladies Respiratoires
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Slow-reacting substance of anaphylaxis (SRS-A), now known as leukotrienes (LTs), plays a key role in asthma pathogenesis. These potent bronchoconstrictors, particularly LTC4, LTD4, and LTE4, significantly impact airway smooth muscle contraction and inflammation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The management of pulmonary tuberculosis in adults notified in Scotland in 1993.

    Respiratory medicine·1999
    Same author

    Procedures for developing a simple scoring method based on unsophisticated criteria for screening children for tuberculosis.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·1998
    Same author

    Surveillance of tuberculosis in Europe. Working Group of the World Health Organization (WHO) and the European Region of the International Union Against Tuberculosis and Lung Disease (IUATLD) for uniform reporting on tuberculosis cases.

    The European respiratory journal·1996
    Same author

    Two men and a bug: one hundred years of tuberculosis in Edinburgh.

    Proceedings of the Royal College of Physicians of Edinburgh·1996
    Same author

    Increasing incidence of tuberculosis in the young and the elderly in Scotland.

    Thorax·1996
    Same author

    Scottish national survey of tuberculosis notifications 1993 with special reference to the prevalence of HIV seropositivity.

    Thorax·1996
    Same journal

    [French version of the guidelines for connective tissue disease-associated ILD].

    Revue des maladies respiratoires·2026
    Same journal

    [Pulmonary expression of an asymptomatic lysosomal storage disorder].

    Revue des maladies respiratoires·2026
    Same journal

    [Factors associated with FEV1 evolution in cystic fibrosis patients treated by CFTR modulator tritherapy].

    Revue des maladies respiratoires·2026
    Same journal

    [Subacute pulmonary coccidioidomycosis: A differential diagnosis of lung cancer].

    Revue des maladies respiratoires·2026
    Same journal

    [Relevance of the ACT score in severe asthma with obesity: A pilot study].

    Revue des maladies respiratoires·2026
    Same journal

    [Automated analysis of mandibular movements for the screening of obstructive sleep apnea].

    Revue des maladies respiratoires·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Immunology
    • Pharmacology

    Context:

    • The role of "slow reacting substance of Anaphylaxis" (SRS-A) in asthma pathogenesis was recognized in the 1950s.
    • Recent research has identified SRS-A as a complex mixture primarily composed of Leukotrienes (LTs) C4, D4, and E4.

    Purpose:

    • To elucidate the specific roles and mechanisms of Leukotrienes (LTs) in the pathogenesis of asthma.
    • To compare the bronchoconstrictive potency of LTs with histamine and identify their primary sites of action.

    Summary:

    • Leukotrienes (LTs) C4, D4, and E4 are derived from arachidonic acid via the 5-lipoxygenase pathway and are potent bronchoconstrictors, exceeding histamine's effects.
    • LTB4 exhibits significant chemotactic activity and an indirect contractile effect on smooth muscle.

    Related Experiment Videos

  • LTC4, LTD4, and LTE4 demonstrate potent in vitro and in vivo bronchoconstrictive effects, with LTC4 and LTD4 predominantly impacting peripheral airways.

    • Impact:

    • Provides a deeper understanding of the biochemical mediators driving asthma pathology.
    • Highlights Leukotrienes as critical targets for novel asthma therapies.
    • Clarifies the differential effects of various Leukotrienes on airway constriction and inflammation.