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[Zinc and chronic enteropathies].

P L Giorgi, C Catassi, A Guerrieri

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |September 1, 1984
    PubMed
    Summary
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    Zinc is crucial for human health, and its deficiency causes symptoms like diarrhea and infections. Proper zinc absorption, influenced by diet, is key to managing conditions like Acrodermatitis Enteropathica.

    Area of Science:

    • Human Nutrition
    • Gastroenterology
    • Mineral Metabolism

    Background:

    • Zinc deficiency is increasingly recognized for its significant impact on human health.
    • Acrodermatitis Enteropathica, a severe genetic disorder, highlights the critical role of zinc absorption.
    • Symptoms of zinc deficiency include skin lesions, chronic diarrhea, and recurrent infections.

    Purpose of the Study:

    • To review the established nutritional importance of zinc.
    • To explore the mechanisms influencing zinc absorption in the small intestine.
    • To discuss the link between zinc deficiency and various gastrointestinal disorders.

    Main Methods:

    • Literature review on zinc's role in human nutrition and health.
    • Analysis of factors affecting zinc bioavailability, including dietary components.

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  • Examination of the relationship between zinc malabsorption and conditions like Acrodermatitis Enteropathica, celiac disease, cystic fibrosis, and Crohn's disease.

    • Main Results:

    • Zinc absorption occurs throughout the small intestine, influenced by dietary factors like phytates (inhibitors) and ligands such as citric acid (facilitators).
    • Conditions characterized by chronic diarrhea often involve impaired zinc absorption.
    • Specific dietary practices for managing infant diarrhea may inadvertently lead to zinc deficiency.

    Conclusions:

    • Zinc is vital for preventing Acrodermatitis Enteropathica and managing symptoms of zinc deficiency.
    • Understanding dietary influences on zinc absorption is crucial for clinical nutrition and managing gastrointestinal diseases.
    • Further research into dietary interventions is needed to optimize zinc status in patients with chronic diarrhea and enteropathies.