Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibiotic nephrotoxicity.

J P Morin, J P Fillastre, B Olier

    Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    REACTION NORMS OF MORPHOLOGICAL TRAITS IN DROSOPHILA: ADAPTIVE SHAPE CHANGES IN A STENOTHERM CIRCUMTROPICAL SPECIES?

    Evolution; international journal of organic evolution·2017
    Same author

    Impact of after-treatment devices and biofuels on diesel exhausts genotoxicity in A549 cells exposed at air-liquid interface.

    Toxicology in vitro : an international journal published in association with BIBRA·2017
    Same author

    Efficacy and Tolerability of Fosinopril 10mg and Hydrochlorothiazide 12.5mg Combination in Elderly Patients with Mild to Moderate Hypertension : A French Multicentre Study.

    Clinical drug investigation·2016
    Same author

    Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels: impact of after treatment devices: oxidation catalyst and particulate filter.

    Mutation research. Genetic toxicology and environmental mutagenesis·2015
    Same author

    Rabbit kidney proximal tubule cells in primary culture: Evaluation of the impact of expressed phenotype on cellular toxic response.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Characterization of Precision-cut Rat Lung Slices in a Biphasic Gas/Liquid Exposure System: Effect of O(2).

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same journal

    Antibiotics and immunity: effects of antibiotics on mitogen responsiveness of lymphocytes and interleukin-2 production.

    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy·1988
    Same journal

    Human lymphoblastoid interferon therapy in chronic hepatitis B virus carriers.

    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy·1988
    Same journal

    Combination treatment of wellferon and zidovudine in asymptomatic HIV p24 Ag positive patients.

    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy·1988
    Same journal

    Treatment of chronic hepatitis B with a combination of acyclovir and human lymphoblastoid interferon.

    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy·1988
    Same journal

    Interferon in the treatment of viral infections of the liver. 24 May 1988. VI Mediterranean Congress of Chemotherapy. Taormina, Italy. Proceedings.

    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy·1988
    Same journal

    Economic implications of oral treatment replacing parenteral therapy in antimicrobial chemotherapy.

    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy·1988
    See all related articles

    Antibiotics can cause kidney damage through immunologic reactions or direct toxicity. Acute interstitial nephropathy (AIN) is rare, while acute tubulo-interstitial nephropathy (ATIN) from aminoglycosides affects 4-10% of patients.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Toxicology

    Background:

    • Antibiotics are a leading cause of drug-associated nephropathy.
    • Nephropathy manifests as acute interstitial nephropathy (AIN) or acute tubulo-interstitial nephropathy (ATIN).
    • These conditions arise from immunologic processes or direct drug toxicity and accumulation.

    Purpose of the Study:

    • To differentiate the mechanisms and clinical presentations of antibiotic-induced nephropathies.
    • To highlight the specific antibiotics implicated in each type of renal injury.
    • To describe the diagnostic features and prognosis of these conditions.

    Main Methods:

    • Review of pathophysiologic mechanisms of antibiotic-induced nephropathy.
    • Categorization of nephropathies based on immunologic versus direct toxic effects.

    Related Experiment Videos

  • Analysis of clinical manifestations, laboratory findings, and pathological features.

    • Main Results:

    • Immunologic AIN, often linked to beta-lactamines (e.g., methicillin) or rifampicin, presents with hematuria, fever, and eosinophilia; renal insufficiency is usually mild.
    • Direct toxic ATIN, predominantly caused by aminoglycosides (4-10% incidence), involves polyuria, tubular damage, and potential tubular necrosis, with rare need for hemodialysis.
    • Pathological findings in toxic ATIN include brush border loss, tubular necrosis, and lysosomal alterations, with tubular regeneration occurring within weeks.

    Conclusions:

    • Antibiotic-induced nephropathy has distinct immunologic and toxic pathways.
    • Aminoglycosides are a significant cause of direct toxic ATIN, characterized by specific tubular damage.
    • Understanding these mechanisms aids in diagnosis and management of antibiotic-related kidney injury.