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Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells
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Published on: June 5, 2015

Generating human monoclonal antibodies

A M Neville, P A Edwards, M J O'Hare

    Medical Oncology and Tumor Pharmacotherapy
    |January 1, 1984
    PubMed

    Present methods and systems for the generation of human monoclonal antibodies are briefly reviewed. The specificities of the available reagents are outlined. It would appear that the generation using hybridoma methods of human monoclonal antibodies to human tumor cell surface antigens is a rare event and that methods of in vitro immunostimulation may have to be used if such antibodies are to be reliably produced.

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