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Related Experiment Videos

Enalapril and autonomic reflexes and exercise performance.

J L Reid, J A Millar, B C Campbell

    Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
    |October 1, 1983
    PubMed
    Summary

    Enalapril effectively lowers blood pressure in young males without causing orthostatic effects or changes in heart rate. This suggests increased parasympathetic tone may explain the lack of reflex tachycardia with ACE inhibitors.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Angiotensin-converting enzyme (ACE) inhibitors are widely used antihypertensive drugs.
    • Understanding the hemodynamic effects of ACE inhibitors like enalapril is crucial.

    Purpose of the Study:

    • To investigate the effects of enalapril on blood pressure and heart rate in normotensive males.
    • To determine if enalapril causes orthostatic hypotension or reflex tachycardia.

    Main Methods:

    • A double-blind, placebo-controlled study involving young, sodium-replete, normotensive males.
    • Administration of enalapril (10 mg) or placebo.
    • Measurement of systolic and diastolic blood pressures in supine and erect postures.
    • Assessment of heart rate, Valsalva maneuver, cold stress, and exercise responses.

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    Main Results:

    • Enalapril significantly reduced both systolic and diastolic blood pressures in supine and erect positions.
    • No significant orthostatic effects or changes in heart rate were observed.
    • Responses to Valsalva maneuver, cold stress, and exercise remained unchanged, indicating no sympatho-inhibitory effect.

    Conclusions:

    • Enalapril effectively lowers blood pressure in normotensive individuals without adverse orthostatic effects.
    • The absence of reflex tachycardia is likely due to increased parasympathetic tone, not sympatho-inhibition.
    • These findings contribute to understanding the cardiovascular safety profile of ACE inhibitors.