Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synopsis: gangliosidoses.

M E Schwab, F Vassella

    Neuropediatrics
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Gangliosidoses are rare neurological diseases caused by enzyme defects, offering insights into metabolic pathways and nervous system cell biology. Studying these conditions, like GM1 and GM2 gangliosidoses, enhances understanding of their complex pathophysiological mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation.

    Nature communications·2017
    Same author

    Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve.

    Cell death and differentiation·2014
    Same author

    Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke.

    Science (New York, N.Y.)·2014
    Same author

    Regeneration of the lesioned spinal cord.

    NeuroRehabilitation·2014
    Same author

    Intracellular Nogo-A facilitates initiation of neurite formation in mouse midbrain neurons in vitro.

    Neuroscience·2013
    Same author

    Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve.

    Cell death & disease·2013
    Same journal

    Prolonged Episodes of Paroxysmal Exertion-Induced Dystonia in Glut1 Deficiency Syndrome.

    Neuropediatrics·2026
    Same journal

    Characteristics and Outcomes of Guillain-Barré Syndrome in Children.

    Neuropediatrics·2026
    Same journal

    Clinical, Radiological, and Prognostic Features of Pediatric Clinically Isolated Syndrome and Risk of Conversion to Multiple Sclerosis: A Single-center Cohort Study.

    Neuropediatrics·2026
    Same journal

    Gait Variability in Children with Periventricular Leukomalacia and Perinatal Stroke: A Comparison of Between-Subject Variability.

    Neuropediatrics·2026
    Same journal

    Why Patient Narratives Belong in Neonatal Research.

    Neuropediatrics·2026
    Same journal

    Successful Treatment of Epileptic Spasms with Perampanel in a Patient with Menkes Disease Caused by a Novel Splice Variant in Intron of ATP7A.

    Neuropediatrics·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Genetics

    Background:

    • Gangliosidoses are rare inherited neurological disorders.
    • These diseases result from specific enzyme deficiencies.
    • They serve as models for studying metabolic pathway disruptions.

    Purpose of the Study:

    • To summarize current knowledge on pathophysiological mechanisms.
    • To focus on GM1 and GM2 gangliosidoses.
    • To enhance understanding of nervous system cell biology.

    Main Methods:

    • Review of existing literature on gangliosidoses.
    • Analysis of pathophysiological mechanisms in GM1 and GM2 gangliosidoses.
    • Synopsis of current scientific understanding.

    Related Experiment Videos

    Main Results:

    • Enzyme defects lead to gangliosidoses, impacting cellular functions.
    • These disorders disrupt specific metabolic pathways.
    • Understanding these mechanisms provides insight into neurological disease.

    Conclusions:

    • Gangliosidoses are valuable models for studying neurological disease.
    • Further research into GM1 and GM2 gangliosidoses is crucial.
    • Investigating these conditions deepens our knowledge of cell biology in the nervous system.