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[Enzymatic phenotype of preneoplastic islands induced in the rat liver by diethylnitrosamine]
M D Estadella1, M J Pujol, J Domingo
1Departamento de Histología y Biología Celular, Facultad de Medicina, Universidad de Barcelona.
Revista Espanola De Oncologia
|January 1, 1983
Abstract:
Diethylnitrosamine was injected to Sprague-Dawley rats after a partial hepatectomy, and enzyme histochemistry analysis was made after 35 weeks in the preneoplastic liver. The areas and volumes of the induced enzyme-deficient islands were calculated for glucose-6-triphosphatase, adenosine triphosphatase, and 5'-nucleotidase. The preneoplastic enzyme-deficient zones showed also an increased incorporation of tritiated thymidine.