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Transport in quantitative structure-activity relationships. VI: Relationship between transport rate constants and
H van de Waterbeemd1, P van Bakel, A Jansen
1Department of Pharmacochemistry, Subfaculty of Pharmacy, University of Leyden, The Netherlands.
Journal of Pharmaceutical Sciences
|September 1, 1981
Abstract:
The transport rate constant of a drug partitioned in a two-phase system from an aqueous to an organic phase (k1obs) and vice versa (k2obs) is a function of the partition coefficient P and of a solvent system-dependent parameter beta. Drug transport is shown to be independent of molecular structure for a number of arbitrary compounds.