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Acetylcholine receptor turnover in mice with passively transferred myasthenia gravis. II. Receptor synthesis
S Wilson1, A Vincent, J Newsom-Davis
1Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
The in vivo synthesis of diaphragm endplate acetylcholine receptors was estimated in mice treated daily with IgG from eight myasthenia gravis patients. Myasthenia gravis IgG preparations which had previously been shown to increase the rate of receptor degradation also increased the rate of receptor synthesis, suggesting the existence of a compensatory mechanism serving to stabilise the number of acetylcholine receptors.
The in vivo synthesis of diaphragm endplate acetylcholine receptors was estimated in mice treated daily with IgG from eight myasthenia gravis patients. Myasthenia gravis IgG preparations which had previously been shown to increase the rate of receptor degradation also increased the rate of receptor synthesis, suggesting the existence of a compensatory mechanism serving to stabilise the number of acetylcholine receptors.