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Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: synthesis and anticancer and other
A M Omar1, A M Farghaly, A A Hazzai
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Journal of Pharmaceutical Sciences
|September 1, 1981
Abstract:
Two novel series of thio compounds bearing internal structural modifications of hexestrol were synthesized as potential anticancer agents. The first contains several N-substituted thiourea functions, and the second contains various N4-substituted-3-thiosemicarbazide moieties in place of one alpha-ethyl group of hexestrol dimethyl ether. The products showed no antileukemic activity in the P-388 lymphocytic leukemia system and did not exhibit any anticonvulsant or estrogenic properties.