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Treatment of cancer by an inducer of reverse transformation

A Brugarolas, M Gosalvez

    Lancet (London, England)
    |January 12, 1980
    PubMed

    Insights

    Thiazolidine-4-carboxylic acid demonstrated potential in reversing tumor cell changes in advanced cancer patients. This compound showed promising responses, particularly in head and neck cancers, leading to cancer regression.

    Area of Science:

    • Oncology
    • Cell Biology
    • Pharmacology

    Background:

    • Thiazolidine-4-carboxylic acid (thioproline) targets tumor cell membranes.
    • It induces reverse transformation of malignant cells towards normal phenotypes.
    • Previous research indicated its potential in altering cancer cell behavior.

    Purpose of the Study:

    • To investigate the efficacy of Thiazolidine-4-carboxylic acid in patients with advanced cancer.
    • To evaluate responses across various dose levels.
    • To assess histological changes associated with the treatment.

    Main Methods:

    • Administration of Thiazolidine-4-carboxylic acid to patients with advanced cancer.
    • Dose-level response evaluation.
    • Histological analysis of tumor biopsies.

    Main Results:

    • Observed responses in patients with advanced cancer, notably epidermoid carcinoma of the head and neck.
    • Significant efficacy noted in cases with pulmonary metastases.
    • Histological evidence of tumor involution and transformation into lower-grade malignancies.

    Conclusions:

    • Thiazolidine-4-carboxylic acid shows therapeutic potential in advanced cancers.
    • The compound facilitates cancer cell normalization and regression.
    • Further investigation into Thiazolidine-4-carboxylic acid for head and neck cancers is warranted.

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