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Related Experiment Videos

Cutaneous histamine response in schizophrenia.

F P Rauscher, H A Nasrallah, R J Wyatt

    The Journal of Clinical Psychiatry
    |February 1, 1980
    PubMed
    Summary

    Schizophrenia patients may not have histamine insensitivity. A reduced skin response to histamine was observed in patients undergoing neuroleptic treatment, not in unmedicated individuals.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Dermatology

    Background:

    • Previous research suggests schizophrenic patients exhibit diminished cutaneous responses to histamine.
    • This phenomenon has been reported in over 12 studies spanning 50 years.

    Purpose of the Study:

    • To investigate the histamine insensitivity in chronic schizophrenic patients.
    • To compare the wheal and flare response in patients, their parents, and healthy controls.

    Main Methods:

    • Examined the wheal and flare response to intradermal histamine.
    • Included chronic schizophrenic patients (medicated and unmedicated), their parents, and a healthy control group.

    Main Results:

    • Histamine insensitivity was not demonstrated in unmedicated schizophrenic patients.
    • A diminished wheal and flare response was observed in patients receiving neuroleptic treatment.

    Conclusions:

    • Cutaneous histamine insensitivity is not a common characteristic of chronic schizophrenia.
    • Neuroleptic treatment may influence the cutaneous response to histamine.

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