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Intermittent high altitude hypoxia.

J Widimsky, B Ostádal, D Urbanová

    Chest
    |March 1, 1980
    PubMed
    Summary
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    Intermittent high altitude (IHA) hypoxia causes pulmonary hypertension and heart changes in rats, but these effects are reversible. Beta blockers can mitigate these negative impacts of IHA exposure.

    Area of Science:

    • Cardiovascular Physiology
    • Altitude Medicine
    • Respiratory Physiology

    Background:

    • Intermittent high altitude (IHA) hypoxia exposure is known to affect cardiovascular and respiratory systems.
    • Pulmonary hypertension and right ventricular hypertrophy are potential consequences of hypoxic conditions.

    Purpose of the Study:

    • To investigate the effects of IHA hypoxia on the myocardium and lesser circulation in adult male Wistar rats.
    • To assess the reversibility of IHA-induced changes and the potential role of polycythemia.
    • To evaluate the efficacy of beta-blocking agents in mitigating these effects.

    Main Methods:

    • Adult male Wistar rats were exposed to intermittent high altitude (IHA) hypoxia.
    • Pulmonary hypertension, right ventricular hypertrophy, and myocardial changes were assessed.

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  • Effects of removing rats from hypoxic conditions and administration of beta-blocking agents were studied.
  • CO polycythemia was experimentally induced to assess its contribution.

    • Main Results:

    • IHA rapidly induced pulmonary hypertension and right ventricular hypertrophy.
    • These changes were reversible upon cessation of IHA exposure.
    • Acute myocardial necrotic changes were observed initially but did not progress with prolonged exposure.
    • IHA-induced pulmonary hypertension was partly attributed to polycythemia.
    • Beta-blocking agents reduced chronic hypoxic pulmonary hypertension, cardiac hypertrophy, and myocardial lesions.

    Conclusions:

    • IHA hypoxia causes significant, yet reversible, cardiovascular and pulmonary changes.
    • Polycythemia contributes to IHA-induced pulmonary hypertension.
    • Beta-blocking agents offer a protective effect against the detrimental impacts of chronic hypoxic exposure.