Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma lipids and mortality: a source of error.

G Rose, M J Shipley

    Lancet (London, England)
    |March 8, 1980
    PubMed
    Summary

    Plasma cholesterol shows a complex relationship with mortality. Low cholesterol is linked to higher cancer deaths initially, but overall mortality correlates positively with cholesterol over time.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Methane, growth and carcase considerations when breeding for more efficient Merino sheep production.

    Animal : an international journal of animal bioscience·2024
    Same author

    Morphologic changes in red blood cells: An illustrated review of clinically important light microscopic findings.

    The Malaysian journal of pathology·2021
    Same author

    A multi-stakeholder participatory study identifies the priorities for the sustainability of the small ruminants farming sector in Europe.

    Animal : an international journal of animal bioscience·2021
    Same author

    Is this a blast? An illustrated practical review on peripheral blood smear examination in the paediatric patient.

    The Malaysian journal of pathology·2020
    Same author

    Bowel cancer surgery outcomes and pre-operative cardiopulmonary exercise testing: insights from real-world data.

    Anaesthesia·2018
    Same author

    Defining the breeding goal for a sheep breed including production and functional traits using market data.

    Animal : an international journal of animal bioscience·2017

    Area of Science:

    • Epidemiology
    • Cardiovascular Disease Research
    • Oncology

    Background:

    • Plasma cholesterol levels are a known risk factor for coronary heart disease (CHD).
    • The relationship between cholesterol and all-cause mortality, particularly non-CHD causes, requires further investigation.
    • Previous studies have primarily focused on the positive association between cholesterol and CHD mortality.

    Purpose of the Study:

    • To investigate the J-shaped relationship between plasma cholesterol and cause-specific mortality in middle-aged men.
    • To examine the association between plasma cholesterol and deaths from coronary heart disease versus other causes.
    • To explore the temporal dynamics of the cholesterol-mortality association.

    Main Methods:

    • Analysis of cause-specific mortality rates in 17,718 men aged 40-64 from the Whitehall Study.
    • A 7.5-year follow-up period was utilized to track mortality events.
    • Data from the Framingham Study were used for replication and validation of findings.

    Main Results:

    • Total mortality exhibited a J-shaped relationship with plasma cholesterol concentration.
    • A strong positive association was observed between plasma cholesterol and coronary heart disease (CHD) deaths.
    • An inverse association was found between plasma cholesterol and non-CHD deaths, particularly cancer mortality, within the first two years of follow-up.
    • This inverse association diminished over time, with total mortality showing a positive correlation with cholesterol beyond two years.

    Conclusions:

    • The J-shaped mortality curve related to plasma cholesterol is influenced by competing associations with CHD and non-CHD causes.
    • The initial inverse relationship between cholesterol and non-CHD mortality may be confounded by undetected preclinical disease, such as cancer.
    • Long-term total mortality demonstrates a positive correlation with plasma cholesterol levels, reinforcing its role as a cardiovascular risk factor.

    Related Experiment Videos