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Related Experiment Videos

Verapamil in chronic stable angina. A controlled study with computerized multistage treadmill exercise.

V B Subramanian, A Lahiri, R Paramasivan

    Lancet (London, England)
    |April 19, 1980
    PubMed
    Summary

    Verapamil significantly improved exercise tolerance and reduced angina symptoms in patients with chronic stable angina pectoris. This calcium channel blocker offers a safe and effective treatment option, with minimal side effects observed.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Chronic stable angina pectoris is a prevalent cardiovascular condition.
    • Effective management strategies are crucial for improving patient quality of life.

    Purpose of the Study:

    • To evaluate the efficacy of verapamil (360 mg daily) in treating chronic stable angina pectoris.
    • To compare verapamil's effects against a placebo in a controlled trial.

    Main Methods:

    • A placebo-controlled, double-blind, crossover trial involving 28 patients.
    • Patients underwent 2-week periods of placebo and verapamil treatment.
    • Exercise treadmill tests were conducted at baseline, 2 weeks, and 4 weeks.

    Main Results:

    • Mean exercise time increased significantly with verapamil (from 6.6 min to 9.2 min at 2 weeks, and 11.2 min at 4 weeks).

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  • Angina did not develop during exercise in 15 patients at 2 weeks and 20 patients at 4 weeks.
  • Trinitrin consumption decreased, and ST-segment changes improved significantly.

    • Conclusions:

    • Verapamil (360 mg daily) demonstrates significant efficacy in managing chronic stable angina pectoris.
    • The treatment showed a favorable safety profile, with constipation and PR-interval prolongation as main side effects.
    • Verapamil may be a valuable therapeutic option for patients with chronic stable angina.