Treating severe maladjustment with pipamperone (Dipiperon)

Individually adapted doses of pipamperone 80-360 mg/day were given for 4 weeks to 25 hospitalized patients (22-72 years) with behaviour disorders due to marked social maladjustment. At the end of the study, nine out of 17 items of a behavior rating scale were significantly improved. Overall progress was good to very good in 15 cases, moderate and insufficient in five each. Pipamperone treatment was considered superior to previous medication in 13 out of 15 patients who had previously been receiving other drugs. The only important side-effects was dryness of the mouth, which was reported by five patients. In four epileptic patients, the course of the underlying disease was not adversely affected.