Oxazolidinediones

Even though the oxazolidinediones have been the subject of many clinical and laboratory studies, no all-inclusive mechanism of action can be formulated from the data reported to date. Studies of neurotransmitter and membrane effects appear to be fruitful areas for future investigations. Also, the search must continue for adequate laboratory models of absence seizures. It is to be expected that our knowledge of the mechanisms of the anticonvulsant effects of the oxazolidinediones will increase as our experiments improve and as our understanding of the pathophysiology of absence seizures expands. However, we still have a long way to go.