Related Experiment Video
Updated: Aug 8, 2026
10:08
Pseudofracture: An Acute Peripheral Tissue Trauma Model
Published on: April 18, 2011
Fractures and dislocations in hemophilia
Clinical Orthopaedics and Related Research
|May 1, 1980
Summary
Hemophilia A patients with fractures and dislocations healed successfully using advanced hemostasis methods. Maintaining adequate Factor VIII levels proved crucial for effective treatment and preventing bleeding complications.
Area of Science:
- Orthopedics
- Hematology
Background:
- Hemophilia A presents challenges in managing orthopedic injuries due to impaired blood clotting.
- Advances in hemostasis management are critical for treating hemophilic patients.
Purpose of the Study:
- To evaluate the efficacy and safety of modern hemostasis management in treating fractures and dislocations in hemophilia A patients.
- To determine optimal Factor VIII levels and treatment durations for various injury severities.
Main Methods:
- Retrospective analysis of 22 hemophilia A patients treated for fractures and dislocations over 10 years.
- Utilized recently developed hemostasis methods combined with conventional orthopedic treatments.
- Maintained specific Factor VIII levels (30% or 60%) based on injury stability and surgical intervention.
Main Results:
- All 22 patients achieved successful fracture and dislocation healing without complications.
- Injuries healed within an average timeframe.
- Patients requiring surgery received higher Factor VIII coverage (60%) for a longer duration (2 weeks).
Conclusions:
- Modern hemostasis management, including Factor VIII concentrate administration, enables successful treatment of orthopedic injuries in hemophilia A patients.
- Appropriate Factor VIII level maintenance is key to preventing bleeding complications.
- While generally safe, careful monitoring is needed, especially in patients with inhibitors or delayed treatment.
Related Concept Videos
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
01:05Introduction to Hemostasis
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
01:20Extrinsic and Intrinsic Pathways of Hemostasis
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
01:24Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...