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Amine storage and function in peptide hormone-producing cells.

F Sundler, R Håkanson, I Lorén

    Investigative & Cell Pathology
    |January 1, 1980
    PubMed
    Summary
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    This study reviews the presence of arylethylamines and histamine in peptide hormone cells. It explores their function in hormone production, storage, and release within these cells.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Endocrinology

    Background:

    • Peptide hormones are crucial signaling molecules.
    • The cellular mechanisms regulating peptide hormones are complex.
    • Arylethylamines and histamine are bioactive amines with known cellular roles.

    Purpose of the Study:

    • To describe the occurrence of arylethylamines and histamine in normal and neoplastic peptide hormone-producing cells.
    • To review the evidence supporting the roles of these amines in hormone formation, storage, and release.

    Main Methods:

    • Literature review of existing studies.
    • Analysis of biochemical and cellular data.
    • Comparative analysis of normal versus neoplastic cell types.

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    Main Results:

    • Arylethylamines and histamine are found in various peptide hormone-producing cell types.
    • Evidence suggests these amines influence peptide hormone synthesis and secretion.
    • Their presence is noted in both healthy and cancerous endocrine cells.

    Conclusions:

    • Arylethylamines and histamine are implicated in the regulation of peptide hormone physiology.
    • Understanding these roles may offer insights into endocrine disorders and cancer.
    • Further research is warranted to elucidate the precise mechanisms involved.